Does a tissue-specific Hox code underlie tumour organotropism?

This project aims to improve outcomes for cancer patients by investigating why tumours spread to certain organs (metastasis) and not others. Parts of Wales, particularly North Wales, have higher cancer incidence and mortality, making metastasis a critical local health concern. Given this research will be implemented in local pathology services if successful, gaining an understanding the molecular mechanisms driving organ-specific metastasis will benefit Welsh patients by enabling earlier risk prediction by Welsh clinicians and the development of targeted therapies to prevent or limit cancer spread.

This project will characterise tissue-specific Hox gene expression in primary and secondary tumours and adjacent normal tissues from Welsh patients. By identifying Hox code patterns that predict organ-specific metastasis, we aim to uncover biomarkers and therapeutic targets. Focusing on local patient samples ensures translational relevance for NHS Wales, supports precision oncology, and addresses regional cancer disparities.

For patients in Wales, this research has the potential to improve metastasis prediction, inform personalised interventions, and reduce secondary cancer risk. In the longer term, it strengthens Wales-led innovation in cancer biology and ensures local patients benefit first these discoveries.